Engineering Questions with Answers - Multiple Choice Questions

MCQs on Self-assembling Macromolecules

1 - Question

Tobacco Mosaic Virus consists of one long molecule of ______________
a) DNA
b) Carbohydrates
c) Glycerol
d) RNA

View Answer

Answer: d
Explanation: In 1955 at the University of California, it was demonstrated that TMV particles consist of one long molecule of RNA which is 6600nucleotides long wound in a helical capsule made of 2130 identical protein subunits.




2 - Question

. TMV particles are not capable of self-assembly.
a) True
b) False

View Answer

Answer: b
Explanation: In the first experiments conducted in 1955, the RNA and protein components of a TMV were separated and then mixed together. After a brief incubation period, the recovered mixture contained infective particles. This confirmed the self-assembly property in TMV.




3 - Question

Ribosomes consist of RNA and _____________
a) carbohydrates
b) nucleic acids
c) proteins
d) nucleotides

View Answer

Answer: c
Explanation: Ribosomes consist of different types of RNAs and proteins. Regardless of the source, all ribosomes contain two subunits of different sizes.




4 - Question

The large (50S) ribosomal subunit of bacteria contains _______ molecules of RNA.
a) 1
b) 2
c) 3
d) 4

View Answer

Answer: b
Explanation: The large (50S) ribosomal subunit of bacteria contains 2 molecules of RNA and approximately 32 different proteins. The smaller 30S subunit contains one RNA molecule and 21 different proteins.




5 - Question

Which protein of the smaller subunit of bacterial ribosome was found to have a function in ribososme assembly?
a) S12
b) S14
c) S16
d) S18

View Answer

Answer: c
Explanation: The S16 protein of the smaller ribosomal subunit 30S was found to have a function solely in ribosome assembly. The deletion of this protein slowed down the in vitro assembly process.




6 - Question

Eukaryotic subunits are not capable of self-assembly.
a) True
b) False

View Answer

Answer: a
Explanation: Ribosomal subunits of bacteria are capable of self-assembly whereas those of eukaryotes are not. Transient association of proteins is required in the in vitro synthesis of eukaryotic ribosomes that don’t even end up in the final product.

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