Engineering Questions with Answers - Multiple Choice Questions

MCQs on Between Replication and Repair

1 - Question

Which form of Xeroderma pigmentosum is observed in patients who cannot synthesize functional polymerase Η?
a) XP III
b) XP IV
c) XP V
d) XP VI

View Answer

Answer: c
Explanation: Patients afflicted with a variant of Xeroderma pigmentosum, XP V are susceptible to developing skin cancer due to sun exposure. It is discovered that the gene encoding replicative polymerase Η.




2 - Question

. Replicative polymerase Η belongs to a family of polymerases involved in ________________
a) translesion synthesis
b) mRNA localization
c) mRNA translation
d) mRNA stability

View Answer

Answer: a
Explanation: The polymerase Η was discovered in 1999, it is a member of family of DNA polymerases having the function of incorporating nucleotides opposite particular types of DNA lesions in the template strand.




3 - Question

. Which if the following polymerases have an unusually spacious active site?
a) DNA polymerases
b) TLS polymerases
c) RNA polymerases
d) DNA helicases

View Answer

Answer: b
Explanation: Translesion synthesis (TLS) polymerases have an unusually spacious active site for accommodating altered nucleotides that would not fit in other replicative enzymes.




4 - Question

. Translesion synthesis polymerases lack processivity.
a) True
b) False

View Answer

Answer: a
Explanation: The translesion synthesis polymerases are only capable of incorporating one to a few nucleotides. They have no proofreading activity and also lack processivity.

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